Palace have had a dreadful run of form which has seen them register only one win in their last ten in the Premier League.
Manchester City come into the game with an opposite run of form, having won their last seven in all competitions, and are just three points off leaders Chelsea.
City do have a massive issue with who to play up front however, as they have no available first-team striker, while captain Vincent Kompany is also out.
Sergio Aguero, Edin Dzeko and Stevan Jovetic are all absent through injury and Manuel Pellegrini will have to resort to using 18-year-old Jose Pozo up top against the Eagles. He also played against Leicester in their last game.
This poses a problem for the champions and one that could see their proficiency drop dramatically as they have only failed to score on one occasion in the league this season, but the lack of a first-team forward could put them in trouble.
Palace on the other hand lay only one point above the relegation zone in 16th, and find themselves dropping down the league rapidly.
They have only won once away from home all season and will need to be at their best to undo the champions at home, with City expected to come out on top, even without a recognised striker.
Score Prediction: Manchester City 2-0 Crystal Palace – City to go level on points with Chelsea for at least two days.
Key Player: Frank Lampard – New York City midfielder Frank Lampard is proving he still has what it takes to perform at the top level as of late, and we expect him to prove the difference once again on Saturday.